Inherited Retinal Disease: IRD
Conditions
Interventions
None listed
Sponsors
Keio University school of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: [Inclusion Criteria for IRD Subject] -Age: Men and women who are at least 20 years old at the time of obtaining consent. -Patients diagnosed with IRD (depending on phenotype). -At the time of obtaining consent, visual acuity of the worse eye is less than or equal to the counting finger (i.e. no light perception, light perception, hand motion, and counting finger) [Inclusion Criteria for Healthy Subject] -Age: Men and women who are at least 20 years old at the time of obtaining consent. -Those who have no severe refractive error (severe refractive error: spherical equivalent -6D and less or +5D and more) -Best-corrected visual acuity (decimal) 1.0 or better of both eyes at the time of obtaining consent.
Exclusion criteria
Exclusion criteria: 1. Healthy people with other eye complications that significantly affect visual field or visual acuity, and with abnormal findings detected by slit-lamp microscopy, fundoscopy, OCT. 2. Those who underwent eye surgery within 3 months. 3. Subjects who have with a history of allergy to the agents to be used in this study, e.g. mydriatic agent, anesthetic agent, etc. 4. Subjects who are diagnosed with dementia or mental illness. 5. Those who are pregnant or lactating. 6. Those who are currently participating in other clinical trials. 7. Those who have participated in a clinical trial for therapeutic purposes within the past 3 months. 8. Those who with a history or suspected or confirmed diagnosis of alcohol or other drug addictions. 9. Those who unable to understand the evaluation and examination procedures. 10. Those who, in the judgment of the principal investigator, are considered to be at risk of becoming ineligible for the study. 11. Those who are judged by the principal investigator or other investigators to be inappropriate for participation in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| -Full-field retinal sensitivity to light by full-field stimulus threshold (FST) testing | — |
Secondary
| Measure | Time frame |
|---|---|
| -Slit-lamp microscopy -Visual acuity test -Visual field test -Fundus photography -Fundus autofluorescence -OCT -ERG -Visual evoked potential -Electrically evoked response -Mobility test -ADL test -Questionnaire regarding QOL | — |
Countries
Japan
Contacts
Public ContactToshihide Kurihara
Keio University School of Medicine Department of Ophthalmology
Outcome results
None listed