In this randomized clinical trial, we aimed to evaluate the effects of AMPs as an addition to SRP on clinical parameters and microbiological biofilms in patients with Stage III and Grade B periodontitis.
Conditions
Interventions
SRP with AMPs group (AMP group)/SRP group
SRP with AMPs group (AMP group)/SRP with minocycline hydrochloride group (Perio group)
Sponsors
Department of Periodontics,Beijing Stomatological Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The inclusion criteria were: (1) at least 20 years old, (2) previously untreated Stage III and Grade B periodontitis by clinically and radiologically17, (3) a minimum of 20 natural teeth in the mouth, and more than 4 molars.
Exclusion criteria
Exclusion criteria: The exclusion criteria were: (1) acute oral lesions or necrotizing ulcerative periodontitis, (2) having received antibiotics within 6 months or the need for antibiotic coverage during experiment, (3) being allergic to minocycline, (4) no orthodontic treatment, (5) a history of systemic diseases, (6) pregnancy, (7) smoker
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| probing depth,clinical attachment level,Bleeding index, and Microbiological results | — |
Countries
Asia(except Japan)
Contacts
Public ContactNannan Han
Beijing Stomatological Hospital, Capital Medical University CCMU
Outcome results
None listed