Heart rate variability-based method for objectively evaluating bone metastasis pain: A pilot study

Heart rate variability-based method for objectively evaluating bone metastasis pain: A pilot study - Heart rate variability-based method for objectively evaluating bone metastasis pain: A pilot study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000047662

Enrollment

Registered

2022-05-15

Start date

2020-07-21

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bone metastasis

Interventions

Obtaining heart beat intervals during 24 h

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: i) pathological diagnosis of cancer; ii) no bone metastasis causing severe pain other than the radiation field; iii) expected prognosis of 3 months or longer; and iv) data available on self-evaluation of pain, anxiety, and depression

Exclusion criteria

Exclusion criteria: RRI could not be accurately evaluated due to arrhythmia or pacemaker, who had psychiatric comorbidities, such as depression or anxiety disorder, or impaired cognitive function, or bone fractures and strong nerve infiltration caused by bone metastasis.

Design outcomes

Primary

Measure	Time frame
Correlation between pain evaluation and autonomic nervous activity (LF / HF, HF, total power) due to heart rate variability	—

Countries

Japan

Contacts

Public ContactKeiko Murofushi

Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital Department of Radiation Oncology

kmurofushi0918@gmail.com03-3823-2101

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026