Down syndrome
Conditions
Interventions
None listed
Sponsors
Teikyo University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inulin clearance measurements were performed at our institution. Consent was obtained for this trial.
Exclusion criteria
Exclusion criteria: 1) Abnormally low (less than 0.5) or abnormally high (greater than 0.5) ratio of urinary inulin excretion to blood inulin concentration 2) GFR greater than 150 ml/min/1.73m2 3) Patients who have had surgery for congenital heart disease or are expected to have surgery in the future 4) Patients with severe renal dysfunction (anuria, oliguria, on dialysis) 5) Respiratory failure or heart failure requiring oxygen administration 6) Patients undergoing treatment for gastrointestinal symptoms or common cold symptoms 7) Women who are pregnant, may become pregnant, or who are breast-feeding 8) Patients with neurological disorders taking antiepileptic drugs 9) Complications of chromosomal or genetic abnormalities other than DS 10) If the doctor in charge judges that the patient is inappropriate to participate in this trial
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Relationship between glomerular filtration rate obtained from inulin clearance and the ratio of reference serum creatinine levels in Down syndrome to serum creatinine levels in affected children. | — |
Secondary
| Measure | Time frame |
|---|---|
| Development of a polynomial approximation for the relationship between glomerular filtration rateobtained from inulin clearance and the commonly used estimated glomerular filtration rate equation. | — |
Countries
Japan
Contacts
Public ContactTomohiko Nishino
Teikyo University School of Medicine Department of Pediatrics
Outcome results
None listed