Alzheimer'
Conditions
Interventions
None listed
Sponsors
Japan Agency for Medical Research and Development
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1)Patients who meet the diagnostic criteria for AD or DLB 2) Age at enrollment: between 50 and 90 years old 3) A total score of 10 or more on the Neuropsychiatric Inventory (NPI) excluding eating behavior abnormalities, and a score of 2 or more on any of the following sub-items: delusions, hallucinations, agitation, depression, anxiety, irritability and sleep disorders. 4)Global CDR score of 0.5, 1 or 2 5)Right-handed 6)There is a family caregiver who lives at home, meets with the patient at least twice a week, and responds appropriately to the patient's BPSD.
Exclusion criteria
Exclusion criteria: 1)Patients who have abnormal findings on brain MRI that indicate other abnormalities than AD or DLB 2)Patients who have history of organic brain diseases, such as head trauma, subarachnoid hemorrhage, or neurosurgery 3)Patients who have history of psychiatric disorders, such as schizophrenia, bipolar disorder, alcoholism, or developmental disorder 4)Patients who have a serious physical illness 5)Patients who the researchers consider unsuitable for the research participants
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sub-item scores of the Neuropsychiatric Inventory (NPI) | — |
Secondary
| Measure | Time frame |
|---|---|
| NPI total score NPIQ total score Information on BPSD and care in real life Empathy disorder rating scale score | — |
Countries
Japan
Contacts
Public ContactHiroaki Kazui
Kochi Medical School,Kochi University, Department of Neuropsychiatry
Outcome results
None listed