The prospective observational study of tissue characterization and information of genome and gene in patients with chronic thromboembolic pulmonary hypertension

The prospective observational study of tissue characterization and information of genome and gene in patients with chronic thromboembolic pulmonary hypertension - Analysis of pulmonary artery intima by single cell RNA sequencing

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000047520

Enrollment

Registered

2022-04-20

Start date

2021-12-23

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic thromboembolic pulmonary hypertension

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1) Patients who is undergoing pulmonary endarterectomy for Chronic thromboembolic pulmonary hypertension. (2) patients 20 years of age or older when we get consent form. (3) Patients for whom written consent has been obtained by the individual.

Exclusion criteria

Exclusion criteria: (1) Patients suffering from hepatitis B and C viruses and human immunodeficiency virus. (2) Other patients who are deemed inappropriate by the physician in charge of the study.

Design outcomes

Primary

Measure	Time frame
Detection of single cell gene expression of the pulmonary artery intima and organized thrombus in patients with chronic thromboembolic pulmonary hypertension undergoing pulmonary endarterectomy.	—

Secondary

Measure	Time frame
Relationship between various data of pulmonary artery intima and data of blood sample in patients with chronic thromboembolic pulmonary hypertension undergoing pulmonary endarterectomy. 1. bulk RNA sequencing 2. exosome analysis 3. histological evaluation 4. single cell ATAC sequencing 5. single cell RNA sequencing of blood sample 6. exosome analysis of blood sample	—

Countries

Japan

Contacts

Public ContactYu Taniguchi

Kobe University Hospital The division of Cardiovascular medicine

yu.taniguchi007@gmail.com078-382-5846

Outcome results