Measurement of opioid sensitivity by sympathetic response evoking threshold during sevoflurane anesthesia.

Measurement of opioid sensitivity by sympathetic response evoking threshold during sevoflurane anesthesia. - Measurement of opioid sensitivity by sympathetic response evoking threshold during sevoflurane anesthesia.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000047425

Enrollment

Registered

2022-04-08

Start date

2022-04-08

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Elective surgery patient over 20 years old

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Adult patients who under go open surgery which require invasive blood pressure measurement during sevoflurane anesthesia. Patients who are informed enough and presents the will of participation to this study by written form.

Exclusion criteria

Exclusion criteria: Patients with irregular R-R intervals on the electrocardiogram. Patients who cannot measure invasive blood pressure in the radial artery. Patients with severe blood circulation or neuropathy in the upper limbs. Patients with severe stenosis or obstructive lesions of coronary arteries and cerebrovascular disease. Patients with contraindicated use of remifentanil or rocuronium.

Design outcomes

Primary

Measure	Time frame
Correlation coefficient between MECK and ROCBP	—

Secondary

Measure	Time frame
Compare correlation coefficient between MECK and ROCBP in our previous study which used propofol with correlation coefficient of this study	—

Countries

Japan

Contacts

Public ContactDaiki Shorin

Division of Clinical Medical Science, Graduate School of Biomedical Sciences, Hiroshima University Department of Anesthesiology and Critical Care

dshorin@hiroshima-u.ac.jp81-082-256-5267

Outcome results