Perioperative duloxetine administration reduces pain after high tibial osteotomy and non-steroidal anti-inflammatory administration

Perioperative duloxetine administration reduces pain after high tibial osteotomy and non-steroidal anti-inflammatory administration - The effect of perioperative duloxetine administration for pain reduction

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000047422

Enrollment

Registered

2022-04-06

Start date

2019-07-15

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

osteoarthritis

Interventions

Patients in the duloxetine group received one 20-mg capsule once daily for 1 week at 3 weeks before surgery and two 20-mg capsules once daily for 2 weeks before surgery. Patients received non-steroida

60 mg) for severe pain, and three tablets per day were permitted as the maximum dose.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Osteoarthritis

Exclusion criteria

Exclusion criteria: Rheumatoid arthritis

Design outcomes

Primary

Measure	Time frame
Numeric rating scale	—

Secondary

Measure	Time frame
Pain catastrophizing Scale Knee Injury and Osteoarthritis Outcome Score (KOOS)	—

Countries

Japan

Contacts

Public ContactShuhei Otsuki

Osaka Medical and Pharmaceutical University Department of orthopedic surgery

Shuhei.otsuki@ompu.ac.jp0726831221

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026