Relationships between digestive disease and gut microbiota

Relationships between digestive disease and gut microbiota - Relationships between digestive disease and gut microbiota

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000047260

Enrollment

2000

Registered

2022-04-01

Start date

2022-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

digestive disease

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients obtained written informed consent after fully explanation of this study and their understandings. 2. Patients diagnosed with Digestive disease(esophageal cancer, gastric cancer, duodenal tumor, small intestine / colon tumor, liver cancer, biliary tract cancer, pancreatic cancer, GERD, gastritis, functional dyspepsia, IBD, chronic hepatitis, cirrhosis, inflammatory disease of biliary and pancreas, etc.)

Exclusion criteria

Exclusion criteria: 1.Women who are pregnant or may be pregnant 2. Patients who have severe organ damage 3. Patients who do not have written consent 4.Unsuitable patients who are judged by doctors registered in this study

Design outcomes

Primary

Measure	Time frame
Relationships between digestive disease and gut microbiota	—

Secondary

Measure	Time frame
1. Evaluation of differences by biopsy and bacterial flora 2. Identification of specific bacteria 3. Assessment of changes in bacterial flora by disease progression 4. Assessment of body fluid composition and properties 5. Assessment of bacterial mRNA by real-time PCR using biopsy tissues 6. Comprehensive evaluation of genome, transcriptome, metabolome, protein, etc. 7. Metabolome analysis of short-chain fatty acids, etc. 8. Relationships between gut microbiota, digestive disease and metabolites of feces 9. Relationships between gut microbiota, digestive disease and rare gas component in exhaled breath 10. Search for effective probiotics/prebiotics by fecal culture and blood immune cell culture	—

Measure

Time frame

1. Evaluation of differences by biopsy and bacterial flora 2. Identification of specific bacteria 3. Assessment of changes in bacterial flora by disease progression 4. Assessment of body fluid composition and properties 5. Assessment of bacterial mRNA by real-time PCR using biopsy tissues 6. Comprehensive evaluation of genome, transcriptome, metabolome, protein, etc. 7. Metabolome analysis of short-chain fatty acids, etc. 8. Relationships between gut microbiota, digestive disease and metabolites of feces 9. Relationships between gut microbiota, digestive disease and rare gas component in exhaled breath 10. Search for effective probiotics/prebiotics by fecal culture and blood immune cell culture

—

Countries

Japan

Contacts

Public ContactKohei Funasaka

Fujita Health University Department of Gastroenterology and Hepatology

k-funa@fujita-hu.ac.jp+81562932324

Outcome results