Optimizing smartphone CBT to maintain and promote mental well-being in the general population: Resilience Enhancement with Smartphone in LIving ENvironmenTs

Conditions

Healthy adults in the community

Tajika A, Toyomoto R, Sakata M, Luo Y, Akechi T, Horikoshi M, Inoue K, Noma H, Cuijpers P, Furukawa TA.

2026-03-04

10.1136/bmjment-2025-302303

Smartphone based cognitive behavioural therapy for adults with no or minimal depressive symptoms in Japan: an exploratory secondary analysis of RESiLIENT trial.

Toyomoto R, Tajika A, Luo Y, Sakata M, Akechi T, Nakayama T, Kondo N, Fukuma S, Horikoshi M, Wason JMS, Noma H, Furukawa TA.

2025-11-19

10.1016/j.lanwpc.2025.101741

Personalised & optimised therapy (POT) algorithm using five cognitive and behavioural skills for subthreshold depression.

Furukawa TA, Noma H, Tajika A, Toyomoto R, Sakata M, Luo Y, Horikoshi M, Akechi T, Kawakami N, Nakayama T, Kondo N, Fukuma S, Wason JMS, Kessler RC, Lutz W, Cuijpers P.

2025-08-201 citations

10.1038/s41746-025-01906-6

Cognitive behavioral therapy skills via a smartphone app for subthreshold depression among adults in the community: the RESiLIENT randomized controlled trial.

Furukawa TA, Tajika A, Toyomoto R, Sakata M, Luo Y, Horikoshi M, Akechi T, Kawakami N, Nakayama T, Kondo N, Fukuma S, Kessler RC, Christensen H, Whitton A, Nahum-Shani I, Lutz W, Cuijpers P, Wason JMS, Noma H.

2025-04-237 citations

10.1038/s41591-025-03639-1

Four 2×2 factorial trials of smartphone CBT to reduce subthreshold depression and to prevent new depressive episodes among adults in the community–RESiLIENT trial (Resilience Enhancement with Smartphone in LIving ENvironmenTs): a master protocol

Toshi A. Furukawa, Aran Tajika, Masatsugu Sakata, Yan Luo, Rie Toyomoto et al. (16 authors)

BMJ Open2023-02-0112 citations

10.1136/bmjopen-2022-067850

Interventions

Smartphone app for behavioral activation (6 weeks) Smartphone app for cognitive restructuring (6 weeks) Smartphone app for problem solving (6 weeks) Smartphone app for assertion training (6 weeks) Sma

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. People of any sex, aged 18 years or older at the time of providing informed consent 2. In possession of their own smartphone (either iOS or Android) 3. Written informed consent for participation in the trial 4. Completion of all the baseline questionnaires within one week after providing informed consent

Exclusion criteria

Exclusion criteria: 1. Cannot read or write Japanese 2. Receiving mental health treatment at the time of screening 3. Screening PHQ-9 total scores (i) of 15 or higher, or (ii) between 10 and 14, inclusive, and scoring 2 or 3 on its item 9

Design outcomes

Primary

Measure	Time frame
Changes in PHQ-9 from baseline to week 6 [Analysis 1]	—

Secondary

Measure	Time frame
1. Incidence of a major depressive episode by week 50 [Analysis 2] 2. Changes in PHQ-9 from baseline to weeks 2, 3, 4, 5; 10, 14, 18, 22, 26, 30, 34, 38, 42, 46, 50 3. Changes in GAD-7 from baseline to weeks 3, 6, 26, 50 4. Changes in ISI from baseline to weeks 3, 6, 26, 50 5. Changes in WEMWBS from baseline to weeks 3, 6, 26, 50 6. Changes in CBT skills from baseline to weeks 6, 26, 50 7. Changes in WSAS, UWES, HPQ and ED-5D-5L from baseline to weeks 6, 50 8. CSQ-3, adherence to smartphone CBT, co-interventions, safety information at weeks 6 and 50	—

Measure

Time frame

1. Incidence of a major depressive episode by week 50 [Analysis 2] 2. Changes in PHQ-9 from baseline to weeks 2, 3, 4, 5; 10, 14, 18, 22, 26, 30, 34, 38, 42, 46, 50 3. Changes in GAD-7 from baseline to weeks 3, 6, 26, 50 4. Changes in ISI from baseline to weeks 3, 6, 26, 50 5. Changes in WEMWBS from baseline to weeks 3, 6, 26, 50 6. Changes in CBT skills from baseline to weeks 6, 26, 50 7. Changes in WSAS, UWES, HPQ and ED-5D-5L from baseline to weeks 6, 50 8. CSQ-3, adherence to smartphone CBT, co-interventions, safety information at weeks 6 and 50

—

Countries

Japan

Contacts

Public ContactAran Tajika

Kyoto University Graduate School of Medicine/School of Public Health Dept of Health Promotion and Human Behavior

furukawa@kuhp.kyoto-u.ac.jp0757539491

Outcome results

None listed