Test to evaluate the relationship between intestinal barrier function and intestinal environment in healthy subjects

Test to evaluate the relationship between intestinal barrier function and intestinal environment in healthy subjects - Test to evaluate the relationship between intestinal barrier function and intestinal environment in healthy subjects

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000047085

Enrollment

Registered

2022-03-07

Start date

2022-03-08

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Men and Women

Interventions

Single dose of sugar solution which contains lactulose 10g and mannitol 5g

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1) Men and women between 20 and 80 years (2) Subjects who have received enough explanation about this study and were able to understand that, then giving written informed consent.

Exclusion criteria

Exclusion criteria: (1) Regular use of certain medicines. (2) Current history of serious illness. (3) Allergy to foods containing sugar alcohols. (4) Subjects who aware that they are prone to diarrhea due to consumption of foods containing sugar alcohols. (5) Subjects who have been pointed out about glucose tolerance and/or renal function from medical checkup and/or doctor within past one year. (6) Subjects who have been determined as ineligible for participating the research by study director.

Design outcomes

Primary

Measure	Time frame
Urinary lactulose-mannitol ratio	—

Secondary

Measure	Time frame
Urinary lactulose concentration Urinary mannitol concentration Gut microbiota Gut metabolite	—

Countries

Japan

Contacts

Public ContactShinnosuke Murakami

Metagen, Inc. Headquarters

research@metagen.co.jp+81-235-64-0330

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026