An attempt of individualized administration of thiopurine by measuring metabolites and metabolic enzyme activities

An attempt of individualized administration of thiopurine by measuring metabolites and metabolic enzyme activities - An attempt of individualized administration of thiopurine by measuring metabolites and metabolic enzyme activities

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000047053

Enrollment

Registered

2022-03-01

Start date

2022-03-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ulcerative colitis, Crohn&#39

Interventions

Collected about 15 ml of blood from patients not receiving thiopurine

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with known polymorphisms of NUDT15 gene (regardless of Crohn's disease, ulcerative colitis, or non-inflammatory bowel disease). 2) Patients who are not receiving thiopurine.

Exclusion criteria

Exclusion criteria: When the physician in charge considers it inappropriate from the viewpoint of human rights protection and the purpose of the research, taking into consideration the health condition, symptoms, age, capacity to consent, and trust relationship with the physician in charge.

Design outcomes

Primary

Measure	Time frame
Correlation of NUDT enzyme activity level with dTG and thiopurine dosage	—

Secondary

Measure	Time frame
Explore factors that regulate NUDT15 enzyme activity, especially factors other than the NUDT15 polymorphism.	—

Countries

Japan

Contacts

Public ContactYusuke Miyatani

Kitasato University Kitasato Institute Hospital Center for Advanced IBD Research and Treatment

yusukemiyatani0703@gmail.com+81-3-3444-6161

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026