Hereditary Breast and Ovarian Cancer
Conditions
Interventions
None listed
Sponsors
Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Healthy BRCA1 / 2 gene mutation carrier 2. After genetic counseling at our hospital 3. Proven to have a BRCA1 or BRCA2 gene mutation 4. Women who are 20 years of age or older on the date of consent acquisition. 5. Fully understanding risk-reducing mastectomy and wish to have risk-reducing mastectomy. 6. ECOG Performance Status (PS) is 0 7. Those that retain the functions of major organs (bone marrow, heart, lungs, liver, kidneys, etc.) 1) White blood cells: 3000 / mm3 or more, less than 12,000 / mm3 2) Hemoglobin: 9.0 g / dl or more 3) Platelets: 100,000 / mm3 or more 4) Total bilirubin: less than 2.0 mg / dL 5) AST, ALT: Facility normal value upper limit x 2 or less 6) Serum creatinine: Within normal facility normal value x 1.5 7) ECG, vital capacity: Those with cardiopulmonary function that can be operated by general anesthesia The inspection data in 1) -7) above shall be within 60 days before the date of consent acquisition. 8. Written consent from the subject to participate in this study
Exclusion criteria
Exclusion criteria: 1. Have active cancer 2. Pregnant and lactating women 3. Have an infectious disease that requires systemic treatment 4. Researchers have determined that participation in this study is inappropriate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Safety of surgery | — |
Countries
Japan
Contacts
Public ContactNoriko Maeda
Yamaguchi University Graduate School of Medicine Department of Gastroenterological, Breast and Endocrine Surgery
Outcome results
None listed