Analysis and prognostic significance of biological samples from patients with severe heart failure requiring ventricular assist device (VAD) and heart transplantation

Analysis and prognostic significance of biological samples from patients with severe heart failure requiring ventricular assist device (VAD) and heart transplantation - Research on biological samples from patients with severe heart failure requiring VAD and heart transplantation

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000047012

Enrollment

Registered

2022-02-26

Start date

2022-02-28

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart failure

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1) Age 18 years or older at the time of obtaining consent (2) Those who have freely and voluntarily consented to participate in this research for research subjects using specimens, and those who do not refuse to participate in the research for research subjects using only medical information.

Exclusion criteria

Exclusion criteria: (1) Persons who are judged by the Principal Investigator to be inappropriate as research subjects.

Design outcomes

Primary

Measure	Time frame
Relationship between findings from various biological samples and incidence of all-cause mortality, cardiovascular death, and heart failure hospitalization	—

Secondary

Measure	Time frame
Relationship between findings from various biological samples and infections (driveline infection, pocket infection, sepsis, mediastinal sinusitis, etc.), heart failure (pump dysfunction, right heart failure), device failure (pump, controller), device thrombosis, hemolysis, arrhythmia, multiple organ failure (liver, kidney, lung, etc.), cerebral neuropathy (stroke, cerebral hemorrhage), gastrointestinal bleeding, and aortic regurgitation. The relationship between findings from various biological samples and acute complications (acute rejection, graft failure, infection, multi-organ failure, renal failure) and chronic complications (transplant coronary artery lesions, malignancy, lymphoma) after heart transplantation. Relationship between findings from various biological samples and patient background, cardiac MRI, cardiac PET, and blood test data.	—

Measure

Time frame

Relationship between findings from various biological samples and infections (driveline infection, pocket infection, sepsis, mediastinal sinusitis, etc.), heart failure (pump dysfunction, right heart failure), device failure (pump, controller), device thrombosis, hemolysis, arrhythmia, multiple organ failure (liver, kidney, lung, etc.), cerebral neuropathy (stroke, cerebral hemorrhage), gastrointestinal bleeding, and aortic regurgitation. The relationship between findings from various biological samples and acute complications (acute rejection, graft failure, infection, multi-organ failure, renal failure) and chronic complications (transplant coronary artery lesions, malignancy, lymphoma) after heart transplantation. Relationship between findings from various biological samples and patient background, cardiac MRI, cardiac PET, and blood test data.

—

Countries

Japan

Contacts

Public ContactSakae Takenaka

Faculty of Medicine and Graduate School of Medicine, Hokkaido University Department of Cardiovascular Medicine

stakenaka1102@gmail.com0117066973

Outcome results