The investigation of the relationship between left atrial appendage and clinical data

The investigation of the relationship between left atrial appendage and clinical data - Analysis of left atrial appendage by single cell RNA sequencing

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000047006

Enrollment

Registered

2022-03-01

Start date

2021-08-20

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial fibrillation

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1) Patients who underwent left atrial appendage resection (2) Patients 20 years of age or older at the time of left atrial appendage resection (3) Patients for whom written consent has been obtained by the individual

Exclusion criteria

Exclusion criteria: (1) Patients taking steroids, autoimmune diseases, undergoing treatment for cancer, or suffering from hepatitis B and C viruses (2) Other patients who are deemed inappropriate by the physician in charge of the study

Design outcomes

Primary

Measure	Time frame
Cluster analysis of single-cell RNA sequencing and cluster analysis of gene expression variation in each cluster on both left atrial appendage with thrombosis and without thrombosis	—

Secondary

Measure	Time frame
Relationship between left atrial appendage collected by left atrial appendage resection and various left atrial appendage data 1. Bulk RNA sequencing 2. micro RNA sequencing 3. Histological evaluation 4. single cell RNA sequencing of blood sample	—

Countries

Japan

Contacts

Public ContactKoji Fukuzawa

Kobe University Hospital The division of Cardiovascular medicine

kfuku@med.kobe-u.ac.jp078-382-5846

Outcome results