Bipolar disorder
Conditions
Interventions
Bipolar disorder patients: To examine NIRS, MRI and clinical assesments
First degree relatives: To examine NIRS, MRI and clinical assesments
Healthy subjects: To examine NIRS, MRI and clinical assesme
Sponsors
Saitama Medical University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Bipolar disorder patients Patients who met the diagnostic criteria for bipolar disorder based on the "Diagnostic and Statistical Manual of Mental Disorder" prepared by the American Psychiatric Association. The proband and two first-degree relatives of the proband, for a total of three people who can participate. Inpatient or outpatient is not required. The diagnosis will be made by clinical diagnostic interview and MINI. It does not matter if they are taking medication or not. First-degree relatives of bipolar disorder patients The proband is participating in this study. They are not schizophrenia or bipolar disorder. They will be screened by clinical interview and structural interview MINI. Healthy subjects Applicants who have not been found to have neurological or psychiatric disorders by clinical interview and MINI.
Exclusion criteria
Exclusion criteria: All subjects Subjects with an intelligence quotient (IQ) of less than 70 or a similar educational background (e.g., graduation from a support school). History of head trauma with loss of consciousness. Serious medical illness (e.g., acute leukemia or recurrent severe asthma attacks) or unstable medical illness (e.g., severe liver damage (AST or ALT of 100 IU or more), renal failure, or abnormal thyroid function) that is currently being treated with different medications or is judged by a physician to require hospitalization. First-degree relatives with neuromuscular diseases (Parkinson's disease, epilepsy, multiple sclerosis, etc.). Those who are judged by the researcher to be unsuitable as subjects (e.g., repeated suicide attempts). Healthy subjects Those who have been diagnosed as having a mental illness by the structured interview (MINI). Those who have a first-degree blood relative with a mental illness. Patients with a history of continuous use of antipsychotic or antidepressant medication.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To examine functional and structural dissimilarities in patients with bipolar disorder and their first-degree relatives, as well as in healthy subjects, by analyzing MRI and NIRS data. | — |
Countries
Japan
Contacts
Public ContactShu Harada
Saitama Medical University Hospital Psychiatry
Outcome results
None listed