Post cardiac arrest syndrome
Conditions
Interventions
Restricted oxygen administration (Intervention): Titration of FiO2 with target SpO2 of 94-95% within 12 hours after return of spontaneous circulation
Regular oxygen administration (Control): Titration
Sponsors
Japanese Association for Acute Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Non-traumatic out-of- and in-hospital cardiac arrest Return of spontaneous circulation in hospital
Exclusion criteria
Exclusion criteria: Spontaneous circulation on hospital arrival No ventilator use for oxygen administration after return of spontaneous circulation (ROSC) GCS equal to or higher than 8 at the time of ROSC ECMO use at the time of ROSC Survival longer than 24 hours after ROSC is not expected Cardiac arrest due to intracranial diseases Poor neurological function before cardiac arrest (Cerebral Performance Category =3 or 4) COVID-19 requiring medications designated for COVID-19 Withholding or withdrawing critical care at the time of ROSC Severe comorbidity that requires strict titration of oxygen, such as chronic lung diseases and congenital diseases Cardiac arrest due to intoxication is suspected Patients in whom SpO2 cannot be measured correctly Patients who participated in other clinical trials that require a therapeutic intervention Patients who need to be arrested, detained, or put in custody by law enforcement or legal agencies Patients who refuse to participate in the trial Patients deemed by a clinical physician to be ineligible to participate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cerebral Performance Category (CPC) at 90 days after the study intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| 30-day mortality, 90-day mortality, hospital-, ICU-, ventilator-, RRT-, and oxygen-free days to day 90, clinical frailty scale at 90 days, hyperoxemia equal to or higher than 300 mmHg in arterial blood within 12 hours, and hypoxia less than 60 mmHg in arterial blood within 12 hours. | — |
Countries
Japan
Contacts
Public ContactRyo Yamamoto
Keio University School of Medicine Department of Emergency and Critical Care Medicine
Outcome results
None listed