New evaluation method of coronary microcirculation

New evaluation method of coronary microcirculation - New evaluation method of coronary microcirculation / NEMCOM

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000046883

Enrollment

200

Registered

2022-03-01

Start date

2022-02-10

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

angina pectoris

Interventions

Caffeine group: Patients take coffee (caffeine 222mg) before coronary angiography. Non-caffeine group: Patients take water 185g before coronary angiography.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with middle to severe coronary stenosis who underwent diagnostic coronary angiography.

Exclusion criteria

Exclusion criteria: Patients with acute coronary syndrome

Design outcomes

Primary

Measure	Time frame
Patients group are divided into caffeine and non-caffeine group. Patients in the caffeine group take coffee (caffeine 222mg) before coronary angiography to make coronary microvessels spastic. In middle to severe stenotic lesions on the coronary angiogram, we conduct coronary pressure test. After FFR test using intravenous adenosine infusion, we add intracoronary nicorandil injection to induce maximal hyperemia. We evaluate the coronary microcirculatory condition using the coronary pressure test data and the character of distal coronary pressure curves.	—

Measure

Time frame

Patients group are divided into caffeine and non-caffeine group. Patients in the caffeine group take coffee (caffeine 222mg) before coronary angiography to make coronary microvessels spastic. In middle to severe stenotic lesions on the coronary angiogram, we conduct coronary pressure test. After FFR test using intravenous adenosine infusion, we add intracoronary nicorandil injection to induce maximal hyperemia. We evaluate the coronary microcirculatory condition using the coronary pressure test data and the character of distal coronary pressure curves.

—

Countries

Japan

Contacts

Public ContactYoshiharu Fujimori

Suwa Central Hospital Department of Cardiology

fujimori.yoshiharu@gmail.com0266721000

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026