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Changes in the expression of glycolytic enzyme PFKFB3 in pancreatic beta cells in Japanese patients with type 2 diabetes

Changes in the expression of glycolytic enzyme PFKFB3 in pancreatic beta cells in Japanese patients with type 2 diabetes - Changes in the expression of glycolytic enzyme PFKFB3 in pancreatic beta cells in Japanese patients with type 2 diabetes

Status
Active, not recruiting
Phases
Unknown
Study type
Unknown
Source
JPRN
Registry ID
JPRN-UMIN000046800
Enrollment
40
Registered
2022-02-01
Start date
2020-02-20
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes

Interventions

None listed

Sponsors

Hokkaido University Hospital
Lead Sponsor
Department of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine
Collaborator

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Agreement to participate to this study

Exclusion criteria

Exclusion criteria: Participants who thought to be inappropriate to enter this study for some reasons by physician's judgments

Design outcomes

Primary

MeasureTime frame
Comparison of PFKFB3-positive beta cell ratio between non-diabetics and patients with type 2 diabetes—

Secondary

MeasureTime frame
1) PFKFB3-positive beta cell ratio in patients with impaired glucose tolerance 2) Relationship between PFKFB3-positive beta cell ratio and patients' background characteristics 3) Association between PFKFB3-positive beta cell ratio and islet amyloid deposition 4) Comparison of PFKFB3 expression intensity in beta cells among non-diabetics, patients with impaired glucose tolerance and those with type 2 diabetes—

Countries

Japan

Contacts

Public ContactNomoto Hiroshi

Hokkaido University Hospital Department of Internal Medicine II

hnomoto@med.hokudai.ac.jp011-706-5915

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026