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Randomized controlled trial of post-resecting hemorrhage suppression effect of adrenergic saline submucosal injection in cold snare polypectomy for colorectal adenomatous polyps less than 10 mm

Randomized controlled trial of post-resecting hemorrhage suppression effect of adrenergic saline submucosal injection in cold snare polypectomy for colorectal adenomatous polyps less than 10 mm - Randomized controlled trial of post-resecting hemorrhage suppression effect of adrenergic saline submucosal injection in cold snare polypectomy for colorectal adenomatous polyps less than 10 mm

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000046770
Enrollment
128
Registered
2022-02-01
Start date
2019-06-24
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

adenomatous polyp and serrated lesion in colorectum less than 10mm

Interventions

Submucosal injection of 0.001% adrenalin-added saline before cold snare polypectomy for adenomas and serrated tumors smaller than 10 mm. Conventional cold snare polypectomy

Sponsors

Showa University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1) Patients with colorectal adenomas and serrated tumors smaller than 10mm. 2) Patients who are 20 to 80 years old at the time of obtaining informed consent. 3) Patients for whom informed consent was obtained in this study.

Exclusion criteria

Exclusion criteria: Patients with above; 1) Incomplete cecal insertion 2) extreme poor bowel preparation 3) Inflammatory bowel disease 4) Active digestive tract bleeding 5) Intestinal stenosis 6) Toxic megacolon 7) Active diverticulitis 8) Familial polyposis coli and Lynch syndrome 9) Not stopping with antithrombotic drugs before examination 10) Unable to rest for a week after colonoscopic procedure 11) Not wishing resection for detected lesions 12) suffering from serious physical and mental illness 13) Judged to be ineligible by the investigator

Design outcomes

Primary

MeasureTime frame
Required time for cold snare polypectomy (time from start of resection to confirmation of natural hemostasis and no residual lesion)

Secondary

MeasureTime frame
Total colon observation and total treatment time, all adverse events that occurred during endoscopic observation and treatment. Bleeding rate after polypectomy. Amount of change in vital signs such as blood pressure and pulse before and after treatment.

Countries

Japan

Contacts

Public ContactAtsushi Katagiri

Showa University Hospital Department of Medicine, Division of Gastroenterology

katsushi@med.showa-u.ac.jp0337848535

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026