healthy subject an/hypohidrosis
Conditions
Interventions
First, skin samples are taken from either the left or right side of the abdomen before heat loading. Next, the other side of the abdomen is used to identify the sweating site using the starch-iodine m
Sponsors
Hiroshima University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Those who are at the age from 20 to 35 years old at the time of obtaining consent. 2. Those who can obtain written consent for participation in this study.
Exclusion criteria
Exclusion criteria: 1. Those who are judged inappropriate by the principal investigator or sub-investigators. 2. Patients with cholinergic urticaria, atopic dermatitis, anhidrosis, hyperhidrosis, and those with a history of such conditions, as well as patients with other skin diseases that may affect the study and those with a history of such conditions. 3. Patients who are taking drugs that affect sweating, such as drugs with anticholinergic effects. 4. Persons with a history of allergy to xylocaine, cefcapene pivoxil hydrochloride hydrate, or loxoprofen. 5. Persons with hypersensitivity to iodine, ethanol, or corn.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Histological (HE staining, immunostaining, etc.) and molecular biological (PCR, in-situ hybridization, etc.) methods will be used to analyze the histological characteristics, proteins, and gene expression of the collected healthy human skin sections before and after sweating induction. | — |
Secondary
| Measure | Time frame |
|---|---|
| Histological characteristics, proteins, and gene expression of collected healthy human skin sections before and after sweat induction will be compared with tissue sections from skin disease patients (after sweat loading) and existing normal skin tissue sections (without sweat loading). | — |
Countries
Japan
Contacts
Public ContactNozomi Yanagida
Hiroshima University Dermatology
Outcome results
None listed