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Adverse events frequency caused by durvalumab and tremelimumab combination therapy: meta-analysis

Adverse events frequency caused by durvalumab and tremelimumab combination therapy: meta-analysis - Adverse events frequency caused by durvalumab and tremelimumab combination therapy: meta-analysis

Status
Active, not recruiting
Phases
Unknown
Study type
Unknown
Source
JPRN
Registry ID
JPRN-UMIN000046751
Enrollment
Unknown
Registered
2022-01-27
Start date
2022-01-27
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

malignancies

Interventions

None listed

Sponsors

Yokohama City University hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients with any malignancies who were treated with combined D+T are patients of interests. We will not question cancer type because our analysis will focus on AE but not efficacy. We will collected AE data of D+T regimen regardless of dose, scheduling, maintenance therapy, and planned number of doses. Perioperative chemotherapy including both adjuvant and neoadjuvant treatment will be accepted.

Exclusion criteria

Exclusion criteria: Concurrent and sequential chemoradiotherapies will be excluded because anti-cancer drug dosage and safety profile are greatly deviated from D+T alone. Besides, regimen with three or more anti-cancer agents will not be allowed. Consequent treatment of D and T, for example, four doses of D followed by maintenance T, was excluded.

Design outcomes

Primary

MeasureTime frame
Frequencies of AEs.

Countries

Japan

Contacts

Public ContactNobuyuki Horita

Yokohama City University Hospital Chemotherapy Center

horitano@yokohama-cu.ac.jp+810081457872800

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026