An exploratory research of pathophysiological relationship between airway and gastrointestinal tract mediated by sensory neuronal dysfunction in asthma with functional gastrointestinal disorders

An exploratory research of pathophysiological relationship between airway and gastrointestinal tract mediated by sensory neuronal dysfunction in asthma with functional gastrointestinal disorders - Sensory neuronal dysfunction in asthma with functional gastrointestinal disorders

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000046728

Enrollment

Registered

2022-02-01

Start date

2022-02-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Asthma, Functional gastrointestinal disorders(FGIDs), Functional dyspepsia(FD)

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients attending our outpatient clinic for asthma and chronic cough or outpatient clinic for functional gastroenteropathy 2. Patients with asthma, cough predominant asthma or cough variant asthma, functional dyspepsia, irritable bowel syndrome

Exclusion criteria

Exclusion criteria: 1. Current smokers or past smokers of 20 pack-years or more 2. Patients with other obvious respiratory complications such as lung cancer, interstitial lung disease, etc. 3. Patients with other obvious organic gastrointestinal complications such as gastric cancer, gastroduodenal ulcer, colorectal cancer, inflammatory bowel disease, etc. 4. Patients who have taken non-steroidal anti-inflammatory drugs within the past 6 months 5. Patients with a history of gastrointestinal tract surgery 6. Pregnant or lactating patients

Design outcomes

Primary

Measure	Time frame
1. To compare capsaicin cough sensitivity between asthmatic patients with and without comorbid FGIDs.	—

Secondary

Measure	Time frame
1. To compare clinical backgrounds and inflammation phenotype(peripheral blood eosinophil and neutrophil counts, exhaled nitric oxide concentration, sputum eosinophil and neutrophil counts, cytokines in serum and sputum) between asthmatic patients with and without comorbid FGIDs. 2. To examine the association of capsaicin cough sensitivity, airway inflammation, and other clinical backgrounds with gastric mucosal inflammation, neuronal remodeling, neuropeptide expression, and TRPV1 expression in asthmatic patients with comorbid FGIDs. 3. To explore factors associated with airway neuronal dysfunction (heightened capsaicin cough sensitivity) in asthmatic patients. 4. To compare gastric mucosal inflammation, neuronal remodeling, neuropeptide expression, and TRPV1 expression between patients with FGIDs with and without comorbid asthma.	—

Measure

Time frame

1. To compare clinical backgrounds and inflammation phenotype(peripheral blood eosinophil and neutrophil counts, exhaled nitric oxide concentration, sputum eosinophil and neutrophil counts, cytokines in serum and sputum) between asthmatic patients with and without comorbid FGIDs. 2. To examine the association of capsaicin cough sensitivity, airway inflammation, and other clinical backgrounds with gastric mucosal inflammation, neuronal remodeling, neuropeptide expression, and TRPV1 expression in asthmatic patients with comorbid FGIDs. 3. To explore factors associated with airway neuronal dysfunction (heightened capsaicin cough sensitivity) in asthmatic patients. 4. To compare gastric mucosal inflammation, neuronal remodeling, neuropeptide expression, and TRPV1 expression between patients with FGIDs with and without comorbid asthma.

—

Countries

Japan

Contacts

Public ContactTakehiro Uemura

Nagoya City University Graduate School of Medical Sciences Department of Respiratory Medicine, Allergy and Clinical Immunology

t50uemu@med.nagoya-cu.ac.jp052-853-8216

Outcome results