Effects of Perioperative Rehabilitation on Blood Tumor-Suppressive MicroRNA Levels and Short- and Long-Term Outcomes in Gastrointestinal Cancer. A Single-Arm Open-Label Study

Effects of Perioperative Rehabilitation on Blood Tumor-Suppressive MicroRNA Levels and Short- and Long-Term Outcomes in Gastrointestinal Cancer. A Single-Arm Open-Label Study - Effects of Perioperative Rehabilitation on Blood Tumor-Suppressive MicroRNA Levels and Short- and Long-Term Outcomes in Gastrointestinal Cancer. A Single-Arm Open-Label Study

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000046598

Enrollment

Registered

2022-01-17

Start date

2022-02-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gastric cancer, colorectal cancer, esophageal cancer, pancreatic cancer

Interventions

Patients scheduled for primary resection of gastrointestinal cancers will undergo preoperative rehabilitation for two weeks. During the rehabilitation stay, patients will be on a high-protein diet, me

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who are scheduled to undergo surgery for gastrointestinal cancer from the date of approval until March 31th in 2024. Patients who can provide written consent to participate in this study of their own free will. Patients who are between 20 and 74 years of age at the time of consent. Any gender. Patients whose diagnosis has been disclosed. Patients who do not have clinically unresectable factors at the time of their first outpatient visit to the Department of Gastrointestinal Surgery.

Exclusion criteria

Exclusion criteria: Patients with a performance status of 2 or higher. Patients who have undergone heart or lung surgery. Patients with a history of ischemic heart disease, arrhythmia, or pacemaker implantation. Patients who are judged to be unable to be rehabilitated due to musculoskeletal diseases or trauma. Patients with other malignant tumors.

Design outcomes

Primary

Measure	Time frame
Evaluation of changes in blood levels of tumor suppressive miR-133b by perioperative rehabilitation intervention in gastrointestinal cancer	—

Secondary

Measure	Time frame
1. Evaluation of changes in blood levels of tumor suppressive miRNAs other than miR-133b by perioperative rehabilitation intervention for gastrointestinal cancer. 2. Effect of perioperative rehabilitation intervention on sarcopenia in gastrointestinal cancer. 3. Prevention of postoperative complications by perioperative rehabilitation intervention in gastrointestinal cancer. 4. Effect of perioperative rehabilitation intervention on long-term prognosis in gastrointestinal cancer.	—

Measure

Time frame

1. Evaluation of changes in blood levels of tumor suppressive miRNAs other than miR-133b by perioperative rehabilitation intervention for gastrointestinal cancer. 2. Effect of perioperative rehabilitation intervention on sarcopenia in gastrointestinal cancer. 3. Prevention of postoperative complications by perioperative rehabilitation intervention in gastrointestinal cancer. 4. Effect of perioperative rehabilitation intervention on long-term prognosis in gastrointestinal cancer.

—

Countries

Japan

Contacts

Public ContactJun Kiuchi

Kyoto Prefectural University of Medicine Division of Digestive Surgery, Department of Surgery

kiuchi@koto.kpu-m.ac.jp075-251-5527

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026