Normative thresholds for upright high resolution manometry metrics and their diagnostic performances

High-resolution manometry with additional maneuvers using the Starlet system : normative thresholds and diagnostic yields for relevant disorders of esophagogastric junction outflow - High-resolution manometry with additional maneuvers using the Starlet system

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000046572

Enrollment

120

Registered

2022-01-07

Start date

2021-09-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

healthy volunteer esophageal motility disorders

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Eligibility criteria for HV were that (i) 20<=age<=65, (ii) no medication which could have effect on gastrointestinal (GI) motility and gastric acid secretion in the last 1 month, (iii) no severe comorbidities (such as heart diseases or cancers).

Exclusion criteria

Exclusion criteria: Exclusion criteria for participants in both studies were (i) allergy for xylocaine, (ii) pregnant or lactating, (iii) low quality tracings due to poor tolerability or artefacts, (iv) upper GI surgeries including endoscopic procedures, (v) relevant organic diseases on esophagogastroduodenoscopy (i.e., carcinomas, Schatzki ring, and para-esophageal hernia), (vi) opioid use in the last 1 month

Design outcomes

Primary

Measure	Time frame
normative thresholds for additional HRM metrics (i.e., upright IRP, upright IBP, IRP during rapid drink challenge)	—

Secondary

Measure	Time frame
sensitivity and specificity of these metrcis for a diagnosis of relevant disorders of esophagogastric junction outflow	—

Countries

Japan

Contacts

Public ContactYoshimasa Hoshikawa

Nippon Medical School Hospital Department of gastroenterology

y-hoshikawa@nms.ac.jp03-3822-2131

Outcome results