Association between serum bilirubin, and inflammation

Fish consumption may be associated with increased serum bilirubin leading to exerting an anti-inflammatory effect: anti-cardiovascular events of fish consumption - Association between fish consumption, serum bilirubin concentration, and anti-Inflammation

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000046557

Enrollment

10000

Registered

2022-01-13

Start date

2022-01-13

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atherosclerotic cardiovascular disease

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Japanese subjects who underwent their annual health checkups

Exclusion criteria

Exclusion criteria: Past medical history of ASCVD No records of frequency of fish intake Serum total bilirubin level more than 2.0 mg/dL Inflammatory disease Positive for HBs antigen Positive for HCV antigen Hepatic cirrhosis Hepatocellular carcinoma Metastatic liver cancer

Design outcomes

Primary

Measure	Time frame
The primary endpoint was the relationship between the weekly amount of fish consumption and serum TB concentration.	—

Secondary

Measure	Time frame
The secondary endpoint is the relationship between serum TB concentration and inflammatory predictive markers of the development of ASCVD, i.e., white blood cell (WBC) count and serum C-reactive protein (CRP) concentration.	—

Countries

Japan

Contacts

Public ContactShigemasa Tani

Nihon University Hospital Health Planning Center

tani.shigemasa@nihon-u.ac.jp0332931711

Outcome results