The retrospective study for Vonoprazan, clarithromycin, and metronidazole regimen for Helicobacter pylori eradication therapy for patients with penicillin allergy in view of clarithromycin-resistance

The retrospective study for Vonoprazan, clarithromycin, and metronidazole regimen for Helicobacter pylori eradication therapy for patients with penicillin allergy in view of clarithromycin-resistance - The retrospective study for Vonoprazan, clarithromycin, and metronidazole regimen for Helicobacter pylori eradication therapy for patients with penicillin allergy in view of clarithromycin-resistance

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000046547

Enrollment

Registered

2022-01-05

Start date

2021-06-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Helicobacter pylori for patients with penicillin allergy

Interventions

PPI (esomeprazole 20mg 2T, lansoprazole 30mg 2T, or rabeprazole na 10mg 2Tb) + clarithromycin 200mg 2T + MNZ 250mg 2T for 7 days Bonoprazole 20 mg 2 T+ clarithromycin 200mg 2T + MNZ 250mg 2T for 7

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Penicillin-allergic patients who received eradication treatment for Helicobacter pylori at our hospital

Exclusion criteria

Exclusion criteria: In the case that the current infection of Helicobacter pylori cannot be confirmed If you do not wish to pay for your own treatment

Design outcomes

Primary

Measure	Time frame
Efficacy of different treatment methods (proton pump inhibitor/bonoprazole + clarithromycin + metronidazole, bonoprazole + metronidazole + sitafloxatin) for penicillin-allergic Helicobacter spp. positive patients at our hospital(To be determined by urea breath test at least 2 months after completion of administration)	—

Secondary

Measure	Time frame
Safety of Treatment Comparison of the difference in efficacy of the following eradication treatments in patients treated with bonoprazan, clarithromycin, and metronidazole with and without clarithromycin resistance	—

Countries

Japan

Contacts

Public Contactkazunori Adachi

Aichi-medical university of medicine gastroenterology

k.adachi@aichi-med-u.ac.jp0561623311

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026