primary progressive aphasia
Conditions
Interventions
Brain amyloid PET with a 20min scan starting 50min post-injection of 370MBq of [18F]florbetapir. Brain tau PET with a 30min scan starting 90min post-injection of 185MBq of [18F]MK-6240. Brain FDG-PET
Sponsors
Kobe City Medical Center General Hospital
Kobe Gakuin University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Hypoperfusion or hypometabolism localized in the left temporal pole revealed by SPECT or PET. 2. Atrophy of the left temporal pole revealed by MRI. 3. Right handed. 4. Linguistic memory more impaired than visual memory in WMSR. 5. Twenty or higher score in MMSE. 6. Able to undergo all the neuropsychological tests of this study. 7. Nine or more years of education.
Exclusion criteria
Exclusion criteria: 1. Suspected of vascular dementia. 2. Cognitive impairment by suspected causes other than neurodegenerative disorders. 3. Suspected of psychiatric disorders such as schizophrenia and depression. 4. Unable to lie on bed for 60min. 5. Extreme claustrophobia. 6. Unable to undergo MRI scan. 7. Anticipatorily unable to undergo all the psychological tests of this study. 8. Possibility of pregnancy. 9. No capacity to consent, for example, due to dementia. 10. Inappropriate for enrollment as determined by principal investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| presence/absence of amyloid deposition evaluated by PET | — |
Secondary
| Measure | Time frame |
|---|---|
| PET images of amyloid, tau and glucose metabolism. Language and semantic cognitive function. | — |
Countries
Japan
Contacts
Public ContactMichio Senda
Kobe City Medical Center General Hospital Department of Molecular Imaging Research
Outcome results
None listed