Cortical reorganization underlying motor recovery after low-frequency repetitive transcranial magnetic stimulation combined with occupational therapy in chronic stroke

Cortical reorganization underlying motor recovery after low-frequency repetitive transcranial magnetic stimulation combined with occupational therapy in chronic stroke - Cortical reorganization underlying motor recovery after low-frequency repetitive transcranial magnetic stimulation combined with occupational therapy in chronic stroke

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000046520

Enrollment

Registered

2022-01-02

Start date

2014-02-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke

Interventions

During the 14-day hospitalization period, each patient received 18 treatment sessions consisting of 20-min low-frequency repetitive transcranial magnetic stimulation and 120-min intensive occupational

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) age at the time of intervention of 18-80 years. 2) time after stroke onset of greater than 12 months. 3) mild-to-moderate upper limb hemiparesis (Action Research Arm Test score >= 16). 4) a plateau in maximum motor recovery after conventional rehabilitation. 5) a history of single subcortical stroke only.

Exclusion criteria

Exclusion criteria: 1) cognitive deficits (Mini-Mental State Examination score <= 23). 2) active systemic or mental illness requiring medical management. 3) seizure. 4) pathological conditions known to be contraindications for rTMS in the guidelines suggested by Wassermann (1998).

Design outcomes

Primary

Measure	Time frame
Changes in neural activation patterns assessed with fMRI before and after therapy	—

Secondary

Measure	Time frame
Fugl-Meyer Assessment Wolf Motor Function Test Action Research Arm Test Motor Activity Log	—

Countries

Japan

Contacts

Public ContactSatoshi Katai

Kakeyu Hospital Department of Neurology

skatai@kakeyu-hp.com0268-44-2111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026