Atrial functional mitral regurgitation
Conditions
Interventions
None listed
Sponsors
Juntendo University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1-Age 20 years or older at the time of enrollment 2-Preserved left ventricular function (left ventricular ejection fraction of 50% or more) 3-Left atrial enlargement (left atrial volume index of 38 mL/m2 or more for men and 41 mL/m2 or more for women. However, if the left atrial volume index is not shown, left atrial diameter of 40mm or more for men and 37mm or more for women) 4-Moderate or severe mitral regurgitation
Exclusion criteria
Exclusion criteria: 1.Patients with organic changes in mitral valve leaflets, i.e. rheumatic changes, prolapse, chordae rupture, infective endocarditis, radiation changes, severe calcification, congenital morphological abnormalities, etc. 2.MR due to mitral valve systolic anterior motion3.Patients with congenital heart disease except for those with a patent foramen ovale 4.Patients with mechanical circulatory assist device 5.Patients with history of mitral valve surgery or heart transplantation 6.Patients with acute heart failure 7.Others who are judged to be inappropriate as research subjects by the principal investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Combined endpoint of heart failure hospitalization and all-cause death | — |
Secondary
| Measure | Time frame |
|---|---|
| Cardiovascular death, non-cardiac death, stroke, major adverse cardiac events, sudden cardiac death, heart failure hospitalization, change in echocardiographic and clinical parameters | — |
Countries
Japan
Contacts
Public ContactNobuyuki Kagiyama
Juntendo University Department of Cardiovascular Biology and Medicine
Outcome results
None listed