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The effects of olfactory stimulation during REM sleep on brain potential

The effects of olfactory stimulation during REM sleep on brain potential - The effects of olfactory stimulation during REM sleep on brain potential

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000046122
Enrollment
16
Registered
2021-12-01
Start date
2021-11-25
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy adult

Interventions

Phenylethyl alcohol (rose-like odor) will be presented at REM sleep during nocturnal sleep at sleep chamber of laboratory, as odor condition. At a later day, odorless stimuli will be also presented as

Sponsors

International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1) They do not have difficulty in filling out Japanese explanatory documents, consent forms, and survey forms. 2) They can stay in the sleep chamber of human sleep laboratory, WPI-IIIS, University of Tsukuba. 3) They have no sleep disorder, olfaction/taste disorder and no history. 4) Their subjective rating of phenylethyl alcohol is familiar odor. "Familiar" is defined as rating as 8 or 9 points, on the scale of "know very little (1 point)" to "neither (5 points)" to "very familiar (9 points)".

Exclusion criteria

Exclusion criteria: 1) Persons with claustrophobia 2) Women who are or may be pregnant 3) Lactating women 4) Patients who may have sudden changeable sickness or have a history 5) Any other person judged by the investigator to be inappropriate as a subject * The above is set for safety considerations.

Design outcomes

Primary

MeasureTime frame
Pre-REM negativity (PRN; Abe et al., 2008), the negative potential occurring prior to rapid eye movement, at Fpz electrode

Countries

Japan

Contacts

Public ContactSatomi Okabe

University of Tsukuba International Institute for Integrative Sleep Medicine (WPI-IIIS)

satomiokabe.experiment@gmail.com029-859-1469

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026