None listed
Conditions
Interventions
Cocoa drink The test food, a beverage containing cocoa polyphenols (30-120 mg as flavanols) per serving, will be consumed. The period of intake is two days with an interval of one week.
placebo drink
Sponsors
Shibaura institute of technology
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Men and women between 40 and 65 years of age at the time of obtaining consent to participate in the study 2.Healthy and free from chronic physical diseases 3.Those who have received sufficient explanation of the purpose and content of the study, are capable of consenting, understand the study well, and voluntarily volunteer to participate, and can agree to participate in the study in writing. 4.Those who are able to come to the site on the designated measurement date and undergo the measurement. 5.Those who have been approved by the study physician to participate in the study.
Exclusion criteria
Exclusion criteria: 1.Those who currently suffer from any kind of disease and are undergoing drug treatment 2.Those who have or are being treated for symptoms of dementia or other memory disorder diseases. 3.Those who have been taking medication for the purpose of disease treatment in the past month (excluding history of headache, menstrual cramps, common cold, etc.) 4.Those who have a history of or are currently suffering from serious disorders of the liver, kidney, heart, lungs, blood, etc. 5.Those with comorbidities or history of comorbidities in the digestive organs 6.Patients with severe anemia 7.Those with food allergies (especially milk) 8.Women: Pregnant, lactating, or planning to become pregnant during the study period 9.Persons with alcoholism or other mental disorders 10.Those with a smoking habit 11.Those who may change their lifestyle during the study period 12.Those at risk of developing seasonal allergic symptoms such as hay fever during the test period. 13.Those who have been in the habit of taking functional foods, health foods, or supplements containing the ingredients (polyphenols) of the test foods at present or within the past three months, and those who plan to do so during the test period. 14.Those who have been in the habit of taking drugs, functional foods, health foods, or supplements claiming to have cognitive effects at present or within the past three months. 15.Have received hormone replacement therapy within the past 6 months. 16.Those who have been treated with hospitalization within the past 6 months, or those who are scheduled to be hospitalized during the examination period. 17.Those who are currently participating in other human clinical trials, and those who have been participating in other human clinical trials for less than one month. 18.Those who have not yet completed the second dose of COVID-19 vaccine. 19.Others who are judged by the investigator to be inappropriate for this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Efficacy endpoint: Cognitive function test by Cognitrax Safety evaluation: Interview of physical condition after the exam | — |
Countries
Japan
Contacts
Public ContactSayaka Konno
Shibaura institute of technology Systems Engineering and Science, Applied Brain Science laboratory
Outcome results
None listed