Effects on various organs in patients who used Remimazolam under general anesthesia

The cardiac electrophysiological effects and the investigation on the incidence of post-operative cognitive dysfunction (POCD) on using of Remimazolam. (a retrospective-test) - The cardiac electrophysiological effects and the investigation on the incidence of post-operative cognitive dysfunction (POCD) on using of Remimazolam. (a retrospective-test)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000045998

Enrollment

120

Registered

2021-11-09

Start date

2021-11-09

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

All patients under general anesthesia

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Patients who underwent general anesthesia using Remimazolam or Propofol at our hospital, regardless of gender. 2) Patients who underwent artificial respiration management by tracheal intubation, etc.

Exclusion criteria

Exclusion criteria: 1) Cases using "excluded drugs" 2) Patients under the age of 20 at the time of obtaining the comprehensive consent form 3) Patients with AST (GOT) or ALT (GPT) of 100 IU / L or higher in general preoperative laboratory tests 4) Patients with Child-Pugh classification B or C 5) Patients with serum creatinine of 2.0 mg / dL or higher in general preoperative laboratory tests 6) Patients who have been using benzodiazepines for a long time 7) When there is a possibility that EEG and BIS values cannot be measured properly due to organic abnormalities in the brain or other surgical procedures. 8) Patients who underwent epidural anesthesia / spinal anesthesia (Because it may be affected by local anesthesia or premedication) 9) Patients with cardiac pacemakers and ICDs (because they are not suitable for electrocardiogram analysis) 10) The research subject has declared his intention to refuse by oral writing. 11) Other patients judged to be inappropriate by the principal investigator

Design outcomes

Primary

Measure	Time frame
Heart rate variability	—

Secondary

Measure	Time frame
Circulatory dynamics (vital signs) POD / POCD incidence	—

Countries

Japan

Contacts

Public ContactShota Tsukimoto

Kindai University Department of Anesthesiology

s-tsukimoto@med.kindai.ac.jp072-366-0221

Outcome results