Urinary megalin excretion as a predictor of kidney outcome in patients with type 2 diabetes or chronic kidney disease

A retrospective study of the association between baseline urinary megalin levels and subsequent estimated glomerular filtration rate in patients with type 2 diabetes or chronic kidney disease - Not applicable

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000045908

Enrollment

800

Registered

2021-10-29

Start date

2007-01-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes Chronic kidney disease

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Type 2 diabetes or chronic kidney disease 2. Urine specimens stored at the Division of Clinical Nephrology and Rheumatology or Department of Applied Molecular Medicine, Niigata University, with informed consent to participate in this clinical study, which was approved by the Ethics Committee of Niigata University (approval no. 191 in 2003)

Exclusion criteria

Exclusion criteria: 1. Severe active infection or severe trauma 2. Pregnancy 3. Deemed ineligible for this study by attending doctors for any medical reason 4. Declining analysis of their urine samples 5. Short observation period (less than 6 months)

Design outcomes

Primary

Measure	Time frame
Associations of urinary megalin excretion and megalin ligand molecules (e.g., alfa 1-microglobulin, beta 2-microglobulin) with changes in estimated glomerular filtration rate, urinary albumin/creatinine ratio, and urinary protein levels	—

Secondary

Measure	Time frame
1. Changes in body weight, blood pressure, and HbA1c during the observation period 2. Changes in other biomarkers (urinary podocalyxin, etc.) during the observation period	—

Countries

Japan

Contacts

Public ContactMichihiro Hosojima

Niigata University Graduate School Of Medical and Dental Science Department of Clinical Nutrition Science, Kidney Research Center

hoso9582@med.niigata-u.ac.jp025-368-9312

Outcome results