Healthy Adults
Conditions
Interventions
Ingest the yogurt drink containing the target lactic acid bacteria every day for 12 weeks.
Ingest the yogurt drink without the target lactic acid bacteria every day for 12 weeks.
Sponsors
KSO Corporation
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Japanese males and females aged from 20 to 64 years old. 2. Subjects who often catch colds or get poor physical conditions. 3. Subjects who received a sufficient explanation of the purpose and contents of this examination, have the capacity to consent, applied with free will with sufficient understanding, and agreed to participate with a written document.
Exclusion criteria
Exclusion criteria: Subjects (who) 1. suffering from, undergoing treatment for, or with a history of serious diseases. 2. have chronic diseases and take medication on a daily basis. 3. have been diagnosed as dry mouth. 4. are unable to abstain from taking supplement, food for specified health use or functional food, or health food that may affect immune function. 5. are unable to abstain from taking food that containing lactic acid bacteria, bifidobacterium, oligosaccharides, or viable bacteria during the study. 6. consistently drink more than the appropriate amount of alcohol. 7. are unable to abstain from alcohol for 2 days prior to screening test and each test. 8. have food allergies. 9. take or have the plan to take medicine for pollen allergy. 10. with digestive diseases affecting digestion and absorption and with a history of digestive surgery (excluding appendicitis). 11. tend to get diarrhea by taking dairy products. 12. are pregnant women, women who intend to become pregnant during the research period, and women who are breastfeeding. 13. are judged to be inappropriate as research subjects by blood tests in screening tests. 14. have a history or current condition of drug or alcohol dependence. 15. are participating in research involving the ingestion of other foods or the use of other medicines or who have participated within one month of obtaining consent, and those who are willing to participate. 16. are judged to be inappropriate as research subjects by the principal investigator. 17. smoke 21 or more cigarettes a day. 18. have the plan to receive the influenza vaccine from 3 weeks before ingestion to the end of the ingestion period. 19. have the plan to receive the COVID-19 vaccine during the ingestion period. 20. work on night shift. 21. plan to travel abroad during the study. 22. has donated more than 200 mL of blood within 1 month or 400 mL of blood within 3 months prior to the date of obtaining consent, or donated blood components.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Physical health questionnaire (local symptoms, systemic symptoms, general symptoms) | — |
Secondary
| Measure | Time frame |
|---|---|
| Salivary sIgA (concentration, secretion rate, secretion amount) NK cell activity Serum IgA level Serum IgG level Serum d-ROMs level Serum BAP level Body temperature POMS 2 Adult Forms | — |
Countries
Japan
Contacts
Public ContactEiji Yoshikawa
KSO Corporation Sales department
Outcome results
None listed