Changes in biological activity and stress after dental calculus removal and the effect of phototherapy

Changes in biological responses and autonomic nervous activity after scaling and the suppressive effect of phototherapy - Inhibitory effect of phototherapy on biological changes after scaling

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000045863

Enrollment

Registered

2021-10-25

Start date

2022-05-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Moderate to severe chronic periodontitis (stage II-IV, grade A-B)

Interventions

Test group 1.26 patients 2. Patients receive subgingival scaling using Er: YAG laser once Control group 1. 26 patients 2. Patients scaling and root planning as using hand scaler once

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Three or more remaining teeth with periodontal pockets of 5 mm or more on the same side

Exclusion criteria

Exclusion criteria: 1. Persons who had received scaling and root planing within the previous 6 months 2. Persons who had taken systemic antibiotics or anti-inflammatory drugs within 3 months before experiment 3. Persons who had severe systemic diseases 4. Smoker

Design outcomes

Primary

Measure	Time frame
Cytokine expression level in serum	—

Secondary

Measure	Time frame
Blood endotoxin level Stress marker level Periodontal examination	—

Countries

Japan

Contacts

Public ContactToshiya Morozumi

Kanagawa Dental University Department of Periodontology

morozumi@kdu.ac.jp+81(46)822-8855

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026