Lung Neoplasms
Conditions
Interventions
The standard drug group will be anesthetized with propofol administered by continuous intravenous infusion to maintain normal anesthesia. Basically, follow the package insert of the drug used. Anesthe
Sponsors
Kitasato University, School of Medicine, Department of Anesthesiology
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients aged 20 years and older undergoing lung surgery with one-lung ventilation and general anesthesia with epidural
Exclusion criteria
Exclusion criteria: If the research subject refuses to cooperate in the research. Contraindications to the use of anesthetics. If the subject has a disease that affects HPV. In the case of a procedure in which one lung ventilation is frequently released intraoperatively, such as surgery for pneumothorax. Patients with longitudinal tumors in the supine position who may require only short periods of one-lung ventilation. If the patient is scheduled to receive intraoperative cardiopulmonary ventilation. Patients with severe chronic lung disease (1 sec rate 50%or less, % lung capacity less than 80%)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To analyze the frequency and severity of hypoxemia in the remimazolam and propofol groups. During anesthesia, arterial partial pressure of oxygen, inhaled oxygen concentration, and P/F ratio (arterial partial pressure of oxygen/Inhaled oxygen concentration) immediately before one-lung ventilation, 30 minutes after the start of one-lung ventilation, and 1 hour after the start of six-lung ventilation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Circulatory changes during anesthesia will be analyzed with respect to heart rate and blood pressure and the amount of boosting agents and other circulatory agonists used. Usage of boosting agents (e.g., neocinesinezine, ephedrine, atropine, and calcicol) during anesthesia Analysis of the presence and frequency of common intraoperative and postoperative complications associated with anesthesia. Intraoperative vital sign abnormalities and other adverse events During anesthesia, continuous monitoring of electrocardiogram, heart rate, percutaneous arterial blood oxygen saturation, and intra-arterial blood pressure will be performed using a monitoring device installed in each operating room to monitor for adverse events such as arrhythmia, deviations in heart rate and blood pressure, and respiratory depression. After administration, the patient should be evaluated for adverse events such as allergic symptoms (erythema, bronchospasm, anaphylaxis), delayed awakening, and convulsions in addition to the above. Analysis of the presence and frequency of other intraoperative and postoperative complications associated with anesthesia Presence of hypertension, hypotension, tachycardia, bradycardia, nausea, vomiting, delirium, intraoperative memory, pre- and post-anesthesia memory at the time of awakening and leaving the room - 24 hours after surgery | — |
Countries
Japan
Contacts
Public ContactTakahiro Honda
Kitasato University School of Medicine, Department of Anesthesiology
Outcome results
None listed