ischemia and no obstructive coronary artery (INOCA)
Conditions
Interventions
None listed
Sponsors
Japan Agency for Medical Research and Development
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients suspected of INOCA who is scheduled to undergo cardia catheterization 2) Patients aged 20 or over who could give informed consent
Exclusion criteria
Exclusion criteria: 1) Patients with a significant organic stenosis (AHA classification over 75% luminal stenosis) in coronary arteries 2) ACS patients 3) Patients with severe kidney disease 4) Patients with a history of severe BA attack 5) Patients with a history of allergy of contrast agent 6) Patients with a history of allergy of acetylcholine 7) Patients who is identified as appropriate in a subject of this study by an attending physician
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sex difference in prevalence and combination of endotypes of coronary functional disorder (e.g. epicardial spasm, microvascular spasm, impaired microvascular diastolic function) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Sex difference in serum levels of endothelin-1, high-sensitive estradiol, and Rho-kinase activity. 2) Sex difference in endothelial and/or vascular smooth muscle functions of isolated resistance vessels by performing isometric tension measurement experiments. 3) Sex difference in the effect of usual therapy for INOCA patients | — |
Countries
Japan
Contacts
Public ContactJun Takahashi
Tohoku university graduate school of medicine Department of cardiovascular medicine
Outcome results
None listed