The study to understand and overcome psychiatric and neurological disorders from an investigation of rapid eye movement (REM) sleep. -The significance of decrease in REM sleep by an analysis of metabolomes in patients with obstructive sleep apnea before and following the treatment-

The study to understand and overcome psychiatric and neurological disorders from an investigation of rapid eye movement (REM) sleep. -The significance of decrease in REM sleep by an analysis of metabolomes in patients with obstructive sleep apnea before and following the treatment- - Understanding and overcoming psychiatric and neurological diseases with approaches from REM sleep

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000045835

Enrollment

Registered

2021-10-26

Start date

2021-11-02

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

OSAS patients whose REM sleep duration is less than 12% of their total sleep duration measured by PSG

Interventions

Although tests are permitted under the health insurance system, to perform PSG several times for the participants (OSAS patients whose REM sleep duration is less than 12% to their total sleep duration

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: The patients with less than 10% of REM sleep identified by PSG

Exclusion criteria

Exclusion criteria: 1. Patients who were already diagnosed with sleep apnea syndrome and treated. 2. Patients with hemodialysis 3. Patients with cancer 4. Patients on oxygen therapy 5. Patients with a cardiac pacemaker 6. Physically disabled patients 7. Patients who refuse to participate in this trial 8. Patients who are judged as inappropriate candidates by doctors

Design outcomes

Primary

Measure	Time frame
Investigation of specific metabolomes and their concentrations which would appear according to changes in REM sleep duration in patients with OSAS before and following CPAP treatment	—

Secondary

Measure	Time frame
Changes in REM sleep duration and ratio to total sleep duration in the patients with OSAS before and following CPAP treatment	—

Countries

Japan

Contacts

Public ContactMamiko Hoshi

Graduate school of medicine, Nihon university Respitory medicine

mema21005@g.nihon-u.ac.jp03-3972-8111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026