The perioperative association between taking sodium-glucose co-transporter (SGLT) 2 inhibitors and ketoacidosis: a single-center, retrospective, observational, cohort study

The perioperative association between taking sodium-glucose co-transporter (SGLT) 2 inhibitors and ketoacidosis: a single-center, retrospective, observational, cohort study - The perioperative association between SGLT2 inhibitors and ketoacidosis

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000045826

Enrollment

200

Registered

2021-10-22

Start date

2021-10-22

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Surgical patients taking SGLT2 inhibitors and postoperative care in general ICU

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Surgical patients taking oral SGLT2 inhibitors and postoperative care in our general ICU 2) Surgical patients aged over 18.

Exclusion criteria

Exclusion criteria: 1) Surgical patients not taking oral SGLT2 inhibitor 2) Surgical patients who require emergency surgery 3) Surgical patients who were judged to be inappropriate as subjects by the study investigators

Design outcomes

Primary

Measure	Time frame
To examine prevalence of postoperative ketoacidosis in the patients taking SGLT2 inhibitors.	—

Secondary

Measure	Time frame
Need of intervention for ketoacidosis. Relations between incidence of ketoacidosis among postoperative patients taking SGLT2 inhibitor and the period stopping the drug. Incidence of intraoperative ketoacidosis. Complications for circulatory dynamic. Relation between strength of surgical stress and incidence of ketoacidosis.	—

Countries

Japan

Contacts

Public ContactYoshihito Fujita

Aichi Medical University Anesthesiology and Intensive Care Medicine

fujita.yoshihito.823@mail.aichi-med-u.ac.jp0561623311

Outcome results