Effect of remimazolam and propofol anesthesia on autonomic nerve activities during Le Fort 1 osteotomy under general anesthesia.

Effect of remimazolam and propofol anesthesia on autonomic nerve activities during Le Fort 1 osteotomy under general anesthesia. - Effect of remimazolam and propofol anesthesia on autonomic nerve activities.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000045824

Enrollment

Registered

2021-10-21

Start date

2021-10-22

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

jaw deformity

Interventions

Remimazolam started at 12 mg/kg/h by continuous intravenous infusion until the loss of consciousness, followed by 1 mg/kg/h to be adjusted as appropriate until the end of surgery. Propofol started at

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients aged 18-45 years scheduled for orthognathic surgery under general anesthesia and an American Society of Anesthesiologists physical status of 1.

Exclusion criteria

Exclusion criteria: ASA-PS II or higher, emergency surgery, inability to obtain consent from the patient, taking benzodiazepines, contraindications to the administration of drugs used in this study, and those under 18 years of age.

Design outcomes

Primary

Measure	Time frame
Changes in heart rate variability and blood pressure variability before and after surgical stimulation with propofol and remimazolam.	—

Countries

Japan

Contacts

Public Contactkyotarou koshika

Tokyo dental college Department of Dental Anesthesiology

koshikakyotarou@tdc.ac.jp03-6380-9113

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026