morbid obesity
Conditions
Interventions
medical treatment
laparoscopic sleeve gastrectomy
Sponsors
Nagasaki university
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Severe obese patients with BMI>32.5kg/m2 attending or hospitalized at Nagasaki University Hospital.
Exclusion criteria
Exclusion criteria: 1)Patients who receive treatment now, or have received treatment within the past 12 months, by bisphosphonates, PTH, anti-RANKL antibodies, or anti-sclerostin antibodies for osteoporosis. 2)Patients with thyroid disease requiring therapeutic intervention, parathyroid disease, primary aldosteronism, Cushing's syndrome, celiac disease, inflammatory bowel disease, renal dysfunction (estimated glomerular filtration rate < 30 ml/min), or hepatic dysfunction (AST > 3 times the upper limit of the reference value). 3)Patients who receive treatment by steroid. 4)Patients who have malignancy. 5)Patients who are pregnant or who may be pregnant. Patients who are lactating. 6)Patients who have participated in other clinical studies within 6 months. 7)Other patients who are judged by the investigators to be inappropriate as research subjects.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in bone microarchitecture at 6,12,24,and 36 months after start of treatment. | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in bone mineral density and bone metabolism markers at 6,12,24,and 36 months after start of treatment. | — |
Countries
Japan
Contacts
Public ContactHIDEYUKI TSUCHIYAMA
Nagasaki university hospital Endocrinology and Metabolism
Outcome results
None listed