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Research to find new indicators for diagnosis and treatment of bladder cancer using exosomes in urine

Identification of novel biomarkers for diagnosis and treatment of bladder cancer using urinary exosomes - Diagnosis and treatment of bladder cancer

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000045726
Enrollment
420
Registered
2021-10-12
Start date
2021-10-25
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

bladder cancer

Interventions

1) Urine specimen In patients with bladder cancer, urine should be collected at the time of diagnosis, when postoperative recurrence is confirmed, before and after surgery during hospitalization for

Sponsors

St.Marianna University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients who are able to collect urine 1) Patients with bladder cancer: diagnosed by various imaging tests, urine cytology, and cystoscopy 2) Patients with benign diseases not accompanied by infection: benign prostatic hyperplasia, ureteral stones, etc. 3) Normal patients: Patients with no obvious organic urological disease such as kidney transplant donors 4) Patients with urinary tract infection: pyelonephritis, cystitis, prostatitis 5) Patients with urological cancer other than bladder cancer: prostate cancer, testicular cancer, renal cell carcinoma

Exclusion criteria

Exclusion criteria: 1) Patients undergoing treatment for malignant diseases in other departments 2) Patients who are judged by the principal investigator to be unsuitable as subjects. 3) Patients who have expressed their intention not to cooperate in this study.

Design outcomes

Primary

MeasureTime frame
Exosomes extracted from urine samples will be analyzed using the ExoScreen method to evaluate the difference in expression of specific exosomes between bladder cancer patients and non-cancer patients.

Secondary

MeasureTime frame
In immunohistochemical staining using surgical specimens, the expression of target substances in cancer tissues, mainly nucleic acids and proteins including miRNAs, will be compared with the expression in non-cancerous tissues.

Countries

Japan

Contacts

Public ContactWataru Usuba

St.Marianna University School of Medicine Department of Urology

w2usuba@marianna-u.ac.jp+81-44-977-8111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026