Healthy adult
Conditions
Interventions
Sponsors
KSO Corporation
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Healthy males and females aged 30 to 74 years old who felt discomfort or pain of the knee. 2. Subjects who are classified into 0-I grade basis of the Kellgren-Lawrence classification. 3. Subjects who got adequate explanation about the purpose and details of the examination, have the capacity to consent, voluntarily participate in understanding, and agree to participate in the examination in writing.
Exclusion criteria
Exclusion criteria: 1. Subjects who are under treatment, have a history, or are suspected to have rheumatoid arthritis. 2. Subjects who have been diagnosed by the investigator as needing treatment for osteoarthritis. 3. Subjects with history of surgical therapy (artificial joint) on knees. 4. Subjects who continuously use compress, topical cream, and/or analgesic agent etc. on knee region. 5. Subjects who have injury of semi-lunar disc or the other knee joint disease. 6. Subjects who received the surgery for chronic knee pain in the past. 7. Subjects who undergo treatment for joints other than the knee (hip, lower back, shoulder, fingers, etc.), who underwent artificial joint surgery, who received the surgery related to joints and bones within 10 years 8. Subjects undergoing treatment for serious chronic diseases such as hepatic disorder, renal disorder, cardiovascular disorder, cerebrovascular disorder, respiratory disorder. 9. Subjects who are unable to stop taking medications, supplements or functional foods that affect the knee joint during the study period. 10. Subjects with allergies to food ingredients contained in the test food. 11. Subjects who hope for pregnancy in the study period, pregnant women, lactating women. 12. Subjects who donated blood of over 200 mL in the past 12 weeks. 13. Subjects who had participated in a study involving the consumption of other foods or drugs or the tests to apply cosmetics and medicines within 1 month retrospectively from the time of consent. Subjects who wish to participate in other studies while participating in this study. 14. Subjects who are judged as unsuitable for the study by the investigator for other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The level of cartilage turnover biomarkers. Amount of change in cartilage turnover biomarkers before intake and after intake. | — |
Secondary
| Measure | Time frame |
|---|---|
| The level of visual analog scale (VAS). Amount of change in visual analog scale (VAS) before intake and after intake. safety assessment Statistical analysis of the level and the amount of change in cartilage turnover biomarkers by the results of visual analog scale (VAS). | — |
Countries
Japan
Contacts
Public ContactYoshika Komori
KSO Corporation Sales department
Outcome results
None listed