Stroke
Conditions
Interventions
None listed
Sponsors
National Cerebral and Cardiovascular Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) patients with stroke (cerebral infarction, intracerebral hemorrhage, subarachnoid hemorrhage) or transient ischemic attack that is developed within 365 days at the time of acquiring written informed consent; 2) patients over 40 years old; 3) patients whose modified Rankin Scale is 4 or less at the time of acquiring consent; 4) patients who have deep ICH or at least 1 deep CMBs on T2*WI in the head MRI performed within 365 days from acquiring consent; 5) the written informed consent has been obtained by the patients themselves or the proxies
Exclusion criteria
Exclusion criteria: 1) patients who are contraindicated to MRI examination because of the presence of some metallic implants such as pacemaker devices; 2) patients who has hemorrhagic factors; 3) patients who participate in other intervention trials; 4) patients who cannot conduct MoCA due to severe dementia, deafness or visual impairment; 5) patients who has no remaining teeth; 6) patients whose participation are judged as inappropriate by the principal investigator or sub-investigators
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| (1) newly developed deep CMBs | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) newly developed lobar or subtentorial CMBs; 2) development of symptomatic intracerebral hemorrhage or ischemic stroke; 3) change in cognitive function assessed by Montreal cognitive assessment (MoCA) and clinical dementia rating; 4) major bleeding defined by the International Society on Thrombosis and Hemostasis criteria; 5) all-cause mortality; and 6) serum antibody titers against periodontal pathogens | — |
Countries
Japan
Contacts
Public ContactYorito Hattori
National Cerebral and Cardiovascular Center Department of Neurology
Outcome results
None listed