Predicting Deterioration of COVID-19 using Biomarkers

Predicting Deterioration of COVID-19 using Biomarkers - PreCOB study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000045462

Enrollment

Registered

2021-09-15

Start date

2021-09-20

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1)COVID-19 confirmed with SARS-CoV-2 PCR test 2)No oxygen requirement on hospital admission

Exclusion criteria

Exclusion criteria: 1) hepatitis C 2) Rheumatoid arthritis and autoimmune diseases 3) Immunosuppressed patients 4) Patient who is expected to die within 48 hours after admission 5) Patient who is considered to be inappropriate for the inclusion to this study by a treating physician

Design outcomes

Primary

Measure	Time frame
Newly initiated oxygen therapy by 14 days after admission	—

Secondary

Measure	Time frame
National Institute of Allergy and Infectious Diseases (NIAID) ordinal scale and Japanese Ministry of Health, Labor, and Welfare severity classification of COVID-19 on Day 0,2,4,6,8,10,12,14, as well as on the day when oxygen therapy is initiated and the day when mechanical ventilation is initiated. In-hospital, 28-day, and 90-day mortality. Hospital-, ICU-, oxygen-, ventilator-, RRT-, and vasopressor-free days until Day 28 after admission. Tracheostomy and time when tracheostomy is performed. Organ failure score such as Sequential Organ Failure Assessment score (SOFA score) and Japanese Association for Acute Medicine disseminated intravascular coagulation criteria (JAAM DIC diagnostic criteria) on Day 0, 2, 7, 14 after admission.	—

Measure

Time frame

National Institute of Allergy and Infectious Diseases (NIAID) ordinal scale and Japanese Ministry of Health, Labor, and Welfare severity classification of COVID-19 on Day 0,2,4,6,8,10,12,14, as well as on the day when oxygen therapy is initiated and the day when mechanical ventilation is initiated. In-hospital, 28-day, and 90-day mortality. Hospital-, ICU-, oxygen-, ventilator-, RRT-, and vasopressor-free days until Day 28 after admission. Tracheostomy and time when tracheostomy is performed. Organ failure score such as Sequential Organ Failure Assessment score (SOFA score) and Japanese Association for Acute Medicine disseminated intravascular coagulation criteria (JAAM DIC diagnostic criteria) on Day 0, 2, 7, 14 after admission.

—

Countries

Japan

Contacts

Public ContactDaiki Kaito

School of Medicine, Keio University Department of Emergency and Critical Care Medicine

hoobar55@keio.jp0332251323

Outcome results