Evaluation of effectiveness and clarification of the mechanism of high concentration hydrogen water intake on systemic inflammatory reaction syndrome

Evaluation of effectiveness and clarification of the mechanism of high concentration hydrogen water intake on systemic inflammatory reaction syndrome - Evaluation of effectiveness and clarification of the mechanism of high concentration hydrogen water intake on systemic inflammatory reaction syndrome

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000045459

Enrollment

Registered

2021-09-13

Start date

2021-10-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

sepsis

Interventions

Consume highly concentrated hydrogen water 150ml per time Have the patient take it in a few minutes using a catheter-tipped syringe directly from the gastric tube 3-4 times daily every 8 hours unti

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) 20 years of age or older 2) Critically ill patients requiring ventilatory management at the time of admission to the Advanced Emergency Center 3) Meet the diagnostic criteria for sepsis

Exclusion criteria

Exclusion criteria: 1) Patients who are expected to die early (within 48 hours of admission) 2) Patients who are at risk for tube administration due to gastrointestinal perforation, gastrointestinal bleeding, etc.

Design outcomes

Primary

Measure	Time frame
Improvement of intestinal microflora	—

Secondary

Measure	Time frame
Clinical course, infectious complications, and changes in cytokines and antioxidant-related substances during the study period	—

Countries

Japan

Contacts

Public ContactKentaro Shimizu

Osaka University Graduate School of Medicine Department of Traumatology and Acute Critical Medicine

shimiken@hp-emerg.med.osaka-u.ac.jp+81668795707

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026