Retrospective study about the prognosis in patients with non-valvular atrial fibrillation who underwent a percutaneous left atrial appendage closure.

Retrospective study about the prognosis in patients with non-valvular atrial fibrillation who underwent a percutaneous left atrial appendage closure. - Retrospective study about left atrial appendage closure device

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000045447

Enrollment

100

Registered

2021-09-10

Start date

2021-09-02

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nonvalvular atrial fibrillation

Interventions

percutaneous left atrial appendage clusore

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: patients with nonvalvular atrial fibrillation who have a high risk of stroke and systemic embolism, based on the CHADS2 or CHA2DS2-VASc scores and a high risk of bleeding with at least one following condition. - Patients with a HAS-BLED score of 3 or higher - Patients with a history of trauma associated with a fall that required treatment for multiple injuries - Patients with a history of diffuse cerebral amyloid angiopathy - Patients who require the concomitant use of two or more antiplatelet agents for an extended period of time (more than 1 year) - Patients with a history of major bleeding that meets the BARC type 3 criteria

Exclusion criteria

Exclusion criteria: 1. patients requiring long-term use of oral anticoagulants for reasons other than non-valvular atrial fibrillation (e.g., patients with implanted mechanical prosthetic valves, patients with hypercoagulable states, or patients with recurrent DVT) 2. patients with evidence of intracardiac (especially intra-atrial) thrombus. 3. patients with atrial septal defect or foramen ovale repair (surgery, device implantation, etc.), or patients with atrial septal defect or foramen ovale repair (surgery, device implantation, etc.). Patients with a history of atrial septal defect or atrial septal suture closure. 4. patients with anatomical structures of the left ventricular ear that are not amenable to closure devices. 5. patients with contraindications to left ventricular closure (transesophageal echocardiography (TEE)) or patients with contraindications to left ventricular closure (e.g., difficulty in inserting transesophageal echocardiography (TEE) probe or catheter required for the procedure). 6. patients with contraindications to anticoagulation, aspirin, or thienopyridine.

Design outcomes

Primary

Measure	Time frame
All-cause death	—

Secondary

Measure	Time frame
cardiovascular death, ischemic stroke, major bleeding event	—

Countries

Japan

Contacts

Public ContactMasato Fukunaga

Kokura Memorial Hospital Department of Cardiology

masato_f0728@yahoo.co.jp093-511-2000

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026