A prospective study on prediction of efficacy of preoperative radiochemotherapy for advanced rectal cancer using liquid biops

A prospective study on prediction of efficacy of preoperative radiochemotherapy for advanced rectal cancer using liquid biops - A prospective study on prediction of efficacy of preoperative radiochemotherapy for advanced rectal cancer using liquid biops

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000045355

Enrollment

Registered

2021-09-02

Start date

2021-04-27

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Advanced Rectal Cancer

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Advanced rectal cancer diagnosed by colonoscopy, CT or MRI imaging

Exclusion criteria

Exclusion criteria: Patient unable to give consent

Design outcomes

Primary

Measure	Time frame
The correlation of the dose of ctDNA and exosome DNA during treatment and the survival.	—

Secondary

Measure	Time frame
Correlation between ctDNA and exosome DNA amounts before, during, and after treatment and recurrence-free survival time Correlation between ctDNA, exosome DNA amount and tumor markers Correlation between ctDNA, exosome DNA amount, response rate of neoadjuvant chemotherapy (RECIST Ver1.1), and disease control Correlation between the amount of ctDNA and exosome DNA and the rate of decrease in the SUVmax value of the primary tumor determined by PET-CT examination Correlation between ctDNA, exosome DNA amount and histological treatment effect (grade based on tumor cell disappearance rate according to Evans criteria) Correlation between ctDNA, exosome DNA amount and resection rate ctDNA, exosome DNA amount and radical resection rate (R1 or R0; R1: state with no macroscopic residual cancer, R0: state with no histological residual cancer) Comparative study of the amount of ctDNA and exosome DNA of the target gene and immunostaining results in surgical resection specimens	—

Measure

Time frame

Correlation between ctDNA and exosome DNA amounts before, during, and after treatment and recurrence-free survival time Correlation between ctDNA, exosome DNA amount and tumor markers Correlation between ctDNA, exosome DNA amount, response rate of neoadjuvant chemotherapy (RECIST Ver1.1), and disease control Correlation between the amount of ctDNA and exosome DNA and the rate of decrease in the SUVmax value of the primary tumor determined by PET-CT examination Correlation between ctDNA, exosome DNA amount and histological treatment effect (grade based on tumor cell disappearance rate according to Evans criteria) Correlation between ctDNA, exosome DNA amount and resection rate ctDNA, exosome DNA amount and radical resection rate (R1 or R0; R1: state with no macroscopic residual cancer, R0: state with no histological residual cancer) Comparative study of the amount of ctDNA and exosome DNA of the target gene and immunostaining results in surgical resection specimens

—

Countries

Japan

Contacts

Public ContactNorio Takemoto

Wakayama medical university 2nd department of surgery

m07055nt@wakayama-med.ac.jp073-441-0613

Outcome results