Evaluation of the intraoral enzyme activity of patients with periodontal disease

Trial of the intraoral peptidase activity of patients with periodontal disease - Trial of intraoral peptidase activity

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000045349

Enrollment

Registered

2021-10-01

Start date

2022-08-12

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

periodontal disease

Interventions

Sampling (saliva, GCF), once

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. The patient who consulted Oral Management Center of Nagasaki University Hospital 2. The patient 20 years or older at the time of the agreement acquisition 3. The patient who received an examination of periodontal tissue

Exclusion criteria

Exclusion criteria: 1. The patient who has difficulty in saliva collection for dry mouth. 2. The patient with the past of antimicrobial and/or the anti-inflammatory dosage for three months before sampling. 3. The patient with the past of the dosage in the periodontal pocket of the antimicrobial. 4. The patient during human DPP4 inhibitor remedy. 5. The previously treated patient with radiation therapy or chemotherapy because of a malignant tumor. 6. The patient who was judged not to participate in this study by us.

Design outcomes

Primary

Measure	Time frame
Peptidase activity and bacterial flora analysis	—

Countries

Japan

Contacts

Public ContactHaruka Nishimata

Nagasaki University Graduate School of Biomedical Sciences Pediatric Dentistry

nishimata@nagasaki-u.ac.jp095-819-7674

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026